Nephrotoxicity definition of nephrotoxicity by the free. Mehta2 abstract drug induced kidney injury is a frequent adverse event which contributes to morbidity and increased healthcare utilization. Cronin, md aminoglycoside nephrotoxicity in experimental animals can be reduced by calcium loading, inducing diabetes, and giving thyroid hormone, while a potassium deficient diet enhances aminoglycoside nephrotoxicity. Animals were injected during 4 or 10 days with saline nacl. Sildenafil ameliorates gentamicininduced nephrotoxicity. Pemetrexed induced acute kidney injury in patients with nonsmall cell lung cancer. As the list of drugs, natural products, industrial chemicals and environmental pollutants that. Melatonin can attenuate ciprofloxacin induced nephrotoxicity. As the use of aminoglycosides became more widespread, the toxic effects of these agents, most notably ototoxicity and nephrotoxicity, became more apparent. Druginduced nephrotoxicity tends to be more common among certain patients and in specific clinical situations. Study of protective effects of stem bark extracts of ficus racemosa in drug induced nephrogenic diabetes insipidus and nephrotoxicity in animal models. Colistininduced nephrotoxicity is a concern with disparity in the reported rates between previous studies.
Nephrotoxic effects of aminoglycosides on the developing. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. The effects induced by gentamicin were significantly reduced by the extract, providing further evidence that this plant has the potential to be used in the treatment of renotoxicity induced by gentamicin. Moreover, great at tention should be paid to drug interactions. More side effects increased nephrotoxicity change in the drug metabolism 4. Symposium on drug effects on the kidney gentamicininduced nephrotoxicity. At the ultrastructural level, the earliest lesions observed concern the. Chronotoxicity of streptomycininduced renal injury in mice jstage.
Colistin is an antibiotic that was introduced many years ago and was withdrawn because of its nephrotoxicity. Molecular mechanisms of colistininduced nephrotoxicity. Different classes of drugs, by virtue of immunological mechanisms or direct toxicity initiate certain stereotyped renal responses. Patients at highest risk of druginduced nephrotoxicity are those with one or more of the following. Druginduced nephrotoxicity accounts for approximately 20% of all acute kidney injuries 1.
However, contrastinduced nephrotoxicity is still the third leading cause of iatrogenic renal failure. In doing so, we will summarize risk factors for nephrotoxicity. There is a growing number of hospitalised patients who develop a druginduced renal problem because increasing numbers of potent drugs have been added to the therapeutic arsenal in recent years. Colistinassociated nephrotoxicity among patients in.
Aminoglycoside type antibiotic gentamicin is one of the leading cause of drug induced nephrotoxicity. Influence of iron, deferoxamine and ascorbic acid on gentamicininduced nephrotoxicity in rats. Nowadays, reemergence of this antibiotic for multidrug resistant gramnegative infections, and a new high dosing regimen recommendation increases concern about its nephrotoxicity. Aminoglycosideinduced nephrotoxicity article pdf available in journal of pharmacy practice 276 september 2014 with 1,253 reads how we measure reads. The effect of fleroxacin on gentamicin induced nephrotoxicity was evaluated with female spraguedawley rats. The precise and complete mechanism of gentamicin nephrotoxicity is still point of speculation and an unfinished story. Further, there were fewer histopathological signs of nephrotoxicity in the groups treated. The medical records of icu patients receiving colistin therapy in hospital serdang and hospital sungai. Get a printable copy pdf file of the complete article 1.
These drugs require special consideration prior to prescribing them. A number of factors have been identified as adding risk to the development of tdfinduced nephrotoxicity including advanced age, low body mass index bmi, diabetes mellitus dm, hypertension htn, couse of other nephrotoxic drugs such as protease inhibitors pi and didanosine, treatment experience, and genetic polymorphism in transporters involved in regulating tdf intracellular. Effects of pretreatment with singledose or intermittent. Pdf gentamicin induced nephrotoxicity in albino mice. Full text druginduced impairment of renal function ijnrd. Pathophysiology of nephrotoxic acute renal failure h umans are exposed intentionally and unintentionally to a variety of diverse chemicals that harm the kidney. Other contributing factors to the nephrotoxicity of ags are the generation of free radicals and the decrease of renal blood flow through local enhancement of the vasoconstrictors, blocking the vasodilators and promoting leukocyte margination. Fartashvand et al gentamicininduced nephrotoxicity in adult. Protective effect of kcl loading in gentamicin nephrotoxicity. Gentamicininduced preconditioning of proximal tubular. Nephrotoxicity associated with ciprofloxacin is uncommon. Melatonin is a wellknown direct free radical scavenger and directly neutralizes a number of free radicals and related toxicants as well as stimulates.
Nephrotoxicity is the side effect that most limits the dose of van, particularly in patients receiving high doses or combinations with other antibiotics, such as aminoglycosides 7. International institute of cellular and molecular pathology. Protective effect of kcl loading in gentamicin nephrotoxicity jeffrey r. We sought to unravel medicinal therapeutic function of w. Pdf effect of withania somnifera on gentamicin induced. Gentamicininduced nephrotoxicity in adult sheep majid fartashvand, ghafour mousavi. Finally, determination of a patients or donors genotype of drugmetabolizing genes or of mol. All compartments of the kidney can be affected by drug induced nephrotoxicity. Druginduced kidney diseases np singh, a ganguli, a prakash abstract druginduced kidney disease constitutes an important cause of acute renal failure and chronic kidney disease in present day clinical practice. Aminoglycosides are concentrationdependent, bactericidal agents that undergo active transport into the cell where they inhibit protein synthesis on the 30s subunit of the bacterial ribosome. This study aims to evaluate colistininduced nephrotoxicity among malaysian population. As explained, oxidative stress and inflammation are two factors contributing to gentamicininduced nephrotoxicity and regarding the antioxidant and antiinflammatory properties of crocin, the present study was designed to evaluate the protective effects of crocin against gentamicininduced renal disturbances in.
Nephrotoxins are substances displaying nephrotoxicity nephrotoxicity should not be confused with the fact that some medications are predominantly excreted by. Druginduced impairment of renal function george sunny pazhayattil, anushree c shirali section of nephrology, yale university school of medicine, new haven, ct, usa abstract. However, nephrotoxicity, which is the main adverse effect of cp administration, limits the drug utilization in cancer treatment. In recent years gentamicin nephrotoxicity is significantly reduced by shifting to once daily dosage as well as by eliminating known risk factors. Nephrotoxicity and agents responsible nephrotoxic injury is damage to one or both kidenys that result from exposure to a toxic substance. The drug induced nephrotoxicity is more common in patients receiving certain medication and undergoing certain specific clinical conditions. Pdf how to prevent, recognize, and treat druginduced. Effect of superoxide dismutase treatment on gentamicin nephrotoxicity in rats. Druginduced nephrotoxicity is a renal dysfunction that occurs as a result of exposure to nephrotoxic. Pemetrexedinduced acute kidney failure following irreversible renal damage. Due to high relative blood flow the kidney is prone to drug induced damage. Gentamicin, an aminoglycoside antibiotic, is used for the treatment of serious gramnegative infections. Sildenafil, a selective phosphodiesterase5 inhibitor, was reported to prevent or decrease tissue injury. The effect of nacetylcysteine on ifosfamideinduced nephrotoxicity.
Our current knowledge of drug induced kidney disease is. There are various forms, and some drugs may affect kidney function in more than one way. Effect of dimethyl sulfoxide on gentamicininduced nephrotoxicity in rats. The 6rs of drug induced nephrotoxicity linda awdishu1,2 and ravindra l. Nephrotoxins are chemicals displaying nephrotoxicity. The aim of this study is to evaluate the potential protective effects of sildenafil on gentamicininduced nephrotoxicity in rats. Contrastinduced nephrotoxicity cin is a form of acute kidney injury that follows intravascular contrast media exposure. N2 aminoglycosides remain critical antibiotics in the armamentarium for serious gramnegative bacterial infections despite their wellknown risk for nephrotoxicity and ototoxicity. Ciprofloxacininduced nephrotoxicity in patients with cancer. Nephrotoxic definition of nephrotoxic by merriamwebster. Amphotericin b remains the antifungal drug of choice for most systemic infections, but a limiting factor for its use is the development of nephrotoxicity. However, its usefulness is limited by its nephrotoxicity. Review boards at each participating center and all patients gave informed consent.
Several drugs and other compounds can induce acute andor chronic nephrotoxicity. Pdf due to high relative blood flow the kidney is prone to druginduced damage. Acute kidney injury serum creatinine increase of 0. Cin may be preventable because its risk factors are well established and the timing of renal insult is commonly known in advance. Nephrotoxicity of ionic and nonionic contrast media in 1196 patients. The 3 clinical syndromes that can be recognised in druginduced nephropathy are acute renal failure, chronic interstitial nephritis and the nephrotic syndrome. Pharmaceutical agents provide diagnostic and therapeutic utility that are central to patient care. However, all agents also carry adverse drug effect profiles. Druginduced nephrotoxicity and its biomarkers ncbi. The effect of coadministration of fosfomycin fom on nedaplatininduced nephrotoxicity in rats was investigated for 6 days. Pdf attenuation of gentamicininduced nephrotoxicity in.
Amphotericin binduced nephrotoxicity is manifested as azotaemia, renal tubular acidosis, impaired renal concentrating ability and electrolyte abnormalities like hypokalaemia and sodium and. Aminoglycosideinduced nephrotoxicity indiana university. Nephrotoxicity definition of nephrotoxicity by medical. While most of these are clinically insignificant, some drugs. Gentamicin nephrotoxicity is one of the common causes of drug induced aki in hospitalized patients. Van induced nephrotoxicity has been reported to occur in 525% of patients 2, 8, although this incidence can rise to 20 35%, with a consequent increase in. Recently, it has been shown that eryngium caucasicum can act as a free. In the present study, we examined effect of oleuropein on the paraoxonase 1 pon1 activity, lipid peroxidation, lipid profile, atherogenic indexes, and relationship of pon1 activity by highdensity lipoproteincholesterol hdlc and atherogenic indices in gentamicin gminduced nephrotoxicity in rats. Low multiples of human therapeutic doses to animals e.
461 113 173 1413 1004 871 449 158 193 1177 773 164 1538 1303 331 1550 1130 28 668 474 858 353 1059 894 409 793 180 1045 1504 39 1121 116 1455 492 1120 1300 443 1369 1482 781 917 252 289 958 749 417 308